Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops).

نویسندگان

  • Naomi Maina
  • Joseph Maina Ngotho
  • Tom Were
  • John Kibuthu Thuita
  • David Mumo Mwangangi
  • John Maina Kagira
  • Joseph Mathu Ndung'u
  • Jeremy Sternberg
چکیده

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fluid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

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منابع مشابه

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عنوان ژورنال:
  • Infection and immunity

دوره 72 5  شماره 

صفحات  -

تاریخ انتشار 2004